PRE AND POSTNATAL DEVELOPMENT

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what is growth

quantitative changes of an individual
changes in shape and tissue composition as well as distribution
cells divide and increase in number known as hyperplasia
cells increase in size known as hypertrophy
change from generalized cells to tissue to specialized tissue(differentiation)

what is development

process of growth from conception to maturation of an individual
orderly, coherent, and progressive changes
changes in nature and functioning of n organ= improved efficiency ad accuracy of performance
development of locomotion
maturation of physiological structures

development of conceptus
embryo ad fetus

embryo=fertilizaion- end of 8th week
organogenic period

fetus
first trimester = vulnerability stage of effects of drugs and radiation
organs develop
second trimester =complete development of an organ system
distinctively human features
third trimester= rapid fetal growth
organ systems become functional

cleavage of the zygote

da 1 = 2 cells +polar body
day 2 = 4 cells+ blastomere
day 2 and 1/2= 9 cells
day 3= 16-cells: morula(latin mulberry)
day4= 58 cells blastocyst
day 5 = balstocyst with zona pelucida trophoblast, inner cell mass, blastocoele

what is compaction mediated by?

E-cadherin

Cavitation

sodium and water move across epithelium-like outer blastomeres

control of embryonic development

regulation of development- specific genes by transcription factors

homeodomain proteins bind to homeobox-containig genes

stages in development from infancy to old age

stage : hyperplasia =rapd mitosis
stage 2 : hyperplasia and hypertrophy
stage 3: hypertrophy +rapid accumulation of fat
muscle and connective tissue

tempo of growth and development of tissue and organs

1) brain
2) body
3) dentition
4) reproductive

factors regulating growth

1)Growth Hormone and insulin-like growth factors= protein synthesis and cell division
thyroid hormone = permissive role( permits other hormones to have an enhanced effect )that contributes to nervous system development
Insulin = supports tissue growth =stimulating protein synthesis
energy is provided in a form of glucose
2) adequate diet
3) absence of chronic stress
4) genetic potential

Growth hormone

increase plasma glucose
increases bone and muscle growth
stimulates protein synthesis
stimulates liver to secrete IGFs
IGFs to stimulate cartilage growth

Somatostatin

growth hormone inhibitor in anterior pituitary gland
fsecreted from the hypothalamus

importance of growth of head

hydrocephalus
water in head

TESTOSTERONE AND OESTRADIOL

BACK LENGTHENS
BOOST GROWTH HORMONE SECRETION
FUSION OF EPIPHYSEAL GROWTH PLATE
CESSATION OF GROWTH

BRAIN GROWTH AND DEVELOPMENT

PHYSIOLGICAL CHANGES DURING AGIN - HEART

DECREASE INTRINSIC HEART RATE AND MAXMAL HEART RATE
BLUNTED BAROFLEX(LESS INCREASE I HEART RATE IN RESPONSE TO DECREASE IN bp)
DECREASE IN DIASTOLC RELAXATION
INCREASE IN ATRIOVENTRICULAR CONDUCTION TIME
INCREASE IN ATRIAL AND VENTRICULAR ATROPY

TELOMEE SHORTENING WITH AGING

TELOMERES SHORTEN
ENZMES NOWN AS TELOMERASE RE-ENHANCES THE GRWOH OF TELOMERES

CAUSES OF INTRA-UTERINE GRWOH RESTRICTION (IUGR)

MATERNAL FACTORS= MEDICAL DISEASE
FETAL FACTORS =CHROM DEFECTS
PLACENTAL FACTORS = UTEROPLACENTAL INSUFFICIENCY

GNRH

NOT ENOUGH CAN CAUSE INFERTILITY